Mineral metabolism disorders, vertebral fractures and aortic calcifications in stable kidney transplant recipients: The role of gender (EMITRAL study).
نویسندگان
چکیده
BACKGROUND AND OBJECTIVES The relationship between mineral metabolism disorders, bone fractures and vascular calcifications in kidney transplant recipients has not been established. METHOD We performed a cross-sectional study in 727 stable recipients from 28 Spanish transplant clinics. Mineral metabolism parameters, the semi-quantification of vertebral fractures and abdominal aortic calcifications were determined centrally. RESULTS Vitamin D deficiency (25OHD3<15ng/ml) was more common in female recipients at CKD-T stages I-III (29.6% vs 44.4%; p=0.003). The inverse and significant correlation between 25OHD3 and PTH was gender-specific and women exhibited a steeper slope than men (p=0.01). Vertebral fractures (VFx) with deformity grade ≥2 were observed in 15% of recipients. Factors related to VFx differed by gender; in males, age (OR 1.04; 95% CI 1.01-1.06) and CsA treatment (OR: 3.2; 95% CI: 1.6-6.3); in females, age (OR 1.07; 95% CI: 1.03-1.12) and PTH levels (OR per 100pg/ml increase: 1.27; 95% CI: 1.043-1.542). Abdominal aortic calcifications were common (67.2%) and related to classical risk factors but not to mineral metabolism parameters. CONCLUSIONS Vitamin D deficiency is more common among female kidney transplant recipients at earlier CKD-T stages, and it contributes to secondary hyperparathyroidism. Prevalent vertebral fractures are only related to high serum PTH levels in female recipients.
منابع مشابه
Vascular calcifications, vertebral fractures and mortality in haemodialysis patients
BACKGROUND Vascular calcifications and the bone fractures caused by abnormal bone fragility, also called osteoporotic fractures, are frequent complications associated with chronic kidney diseases (CKD). The aim of this study was to investigate the association between vascular calcifications, osteoporotic bone fractures and survival in haemodialysis (HD) patients. METHODS A total of 193 HD pat...
متن کاملSurvival rate of recipients of kidney transplantation from Cadaver donors in Tabriz transplant patients in Imam Reza Hospital during the last 5 years
Introduction: Determining the efficacy of this procedure and determining the survival rate of patients after transplant surgery and determining the role of some factors in this survival is important. Therefore, the aim of this study was to evaluate the prevalence of cadaveric donor kidney transplant recipients in transplant patients of Imam Reza Hospital in Tabriz during the last 5 years. Mate...
متن کاملFrequency of bone mineral density testing in adult kidney transplant recipients from Ontario, Canada: a population-based cohort study
BACKGROUND We lack consensus on the clinical value, frequency, and timing of bone mineral density (BMD) testing in kidney transplant recipients. This study sought to determine practice patterns in BMD testing across kidney transplant centres in Ontario, Canada, and to compare the frequency of testing in kidney transplant recipients to non-transplant reference groups. METHODS Using healthcare ...
متن کاملIs management of angiomyolipoma different after kidney transplantation?
mineral density changes within six months of renal transplantation. increased bone turnover and low bone density in long-term survivors to kidney transplantation. Posttransplant bone disease: evidence for a high bone resorption state. mineral density in kidney transplant recipients and patients on hemodialysis: a comparison with healthy individuals. Comparison of alendronate and pamidronate on ...
متن کاملDetermining an accurate method to estimate GFR in renal transplant recipients with stable serum creatinine levels
Introduction:Detecting renal allograft dysfunction early will allow timely diagnosis and treatment. There is no objective recommendation by national kidney societies for glomerular filtration rate (eGFR) estimation in post-transplant setting. 99mTc-DTPA Technetium-99m Diethylene triamine penta acetic acid) renogram can identify early renal dysfunction much before ser...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia
دوره 36 3 شماره
صفحات -
تاریخ انتشار 2016